The cognitive processing of spatial relations in Euclidean diagrams is central to the diagram-based geometric practice of Euclid's Elements. In this study, we investigate this processing through two dichotomies among spatial relations—metric vs topological and exact vs co-exact—introduced by Manders in his seminal epistemological analysis of Euclid's geometric practice. To this end, we carried out a two-part experiment where participants were asked to judge spatial relations in Euclidean diagrams in a visual half field task design. In the first part, we (...) tested whether the processing of metric vs topological relations yielded the same hemispheric specialization as the processing of coordinate vs categorical relations. In the second part, we investigated the specific performance patterns for the processing of five pairs of exact/co-exact relations, where stimuli for the co-exact relations were divided into three categories depending on their distance from the exact case. Regarding the processing of metric vs topological relations, hemispheric differences were found for only a few of the stimuli used, which may indicate that other processing mechanisms might be at play. Regarding the processing of exact vs co-exact relations, results show that the level of agreement among participants in judging co-exact relations decreases with the distance from the exact case, and this for the five pairs of exact/co-exact relations tested. The philosophical implications of these empirical findings for the epistemological analysis of Euclid's diagram-based geometric practice are spelled out and discussed. (shrink)

The clinical introduction of medical devices often occurs with relatively little oversight, regulation and (long-term) follow-up. Some recent controversies underscore the weaknesses of the current regime, such as the complications surrounding the metal-on-metal hip implants and the scandal surrounding the global breast implant scare of silicone implants made by France's Poly Implant Prothese (PIP) Company. The absence of national registries hampered the collection of reliable information on the risks and harms of the PIP breast implants. To warrant long-term safety, a (...) case can be made for mandatory post-marketing surveillance by means of the establishment of compulsory registries. In this edition of Public Health Ethics, Schofield calls for debate on how such a registry system should be initiated and maintained and how it would relate to the ethical requirement of consent. Here we use breast implant registries as a case to discuss whether and when a so-called ‘thick opt-out’ would be an appropriate method to include people in medical device registries. We conclude that a thick opt-out procedure for medical device registries is only justifiable in cases where inclusion does not involve burdens (or very low), when it does not involve a sensitive subject and when the data are stored anonymously (or at least not directly linked to the medical record). Otherwise, inclusion should be sought by means of an opt-in. (shrink)

This paper elaborates on conceptual, empirical and practical arguments why corporations need to focus on their social dimensions, in order to further enhance organizational performance. The paper starts with an introduction on the general trend towards inclusiveness and connectedness. It then elaborates on the phase-wise development of cultures and organizational structures. Managing corporate improvement by building cultures of trust is the central focus of this contribution. By showing the cultural dimensions of Great Places to Work and their workplace practices, worthwhile (...) experiences leading to organizational improvement and superior financial performance are demonstrated. (shrink)

Rapid developments in Artificial Intelligence are leading to an increasing human reliance on machine decision making. Even in collaborative efforts with Decision Support Systems (DSSs), where a human expert is expected to make the final decisions, it can be hard to keep the expert actively involved throughout the decision process. DSSs suggest their own solutions and thus invite passive decision making. To keep humans actively ‘on’ the decision-making loop and counter overreliance on machines, we propose a ‘reflection machine’ (RM). This (...) system asks users questions about their decision strategy and thereby prompts them to evaluate their own decisions critically. We discuss what forms RMs can take and present a proof-of-concept implementation of a RM that can produce feedback on users’ decisions in the medical and law domains. We show that the prototype requires very little domain knowledge to create reasonably intelligent critiquing questions. With this prototype, we demonstrate the technical feasibility to develop RMs and hope to pave the way for future research into their effectiveness and value. (shrink)

BackgroundThe COVID-19 pandemic has created ethical challenges for intensive care unit (ICU) professionals, potentially causing moral distress. This study explored the levels and causes of moral distress and the ethical climate in Dutch ICUs during COVID-19.MethodsAn extended version of the Measurement of Moral Distress for Healthcare Professionals (MMD-HP) and Ethical Decision Making Climate Questionnaire (EDMCQ) were online distributed among all 84 ICUs. Moral distress scores in nurses and intensivists were compared with the historical control group one year before COVID-19. ResultsThree (...) hundred forty-five nurses (70.7%), 40 intensivists (8.2%), and 103 supporting staff (21.1%) completed the survey. Moral distress levels were higher for nurses than supporting staff. Moral distress levels in intensivists did not differ significantly from those of nurses and supporting staff. “Inadequate emotional support for patients and their families” was the highest-ranked cause of moral distress for all groups of professionals. Of all factors, all professions rated the ethical climate most positively regarding the culture of mutual respect, ethical awareness and support. “Culture of not avoiding end-of-life-decisions” and “Self-reflective and empowering leadership” received the lowest mean scores. Moral distress scores during COVID-19 were significantly lower for ICU nurses (p < 0.001) and intensivists (p < 0.05) compared to one year prior.ConclusionLevels and causes of moral distress vary between ICU professionals and differ from the historical control group. Targeted interventions that address moral distress during a crisis are desirable to improve the mental health and retention of ICU professionals and the quality of patient care. (shrink)

Ordo V comprises works on religious instruction. This first volume of Ordo V in the Amsterdam edition of the Latin texts of Erasmus offers one of Erasmus’ earliest writings De contemptu mundi and other theological works, including the Explanation on the Apostles’ Creed , a book on prayer and a work on the Christian’s preparation on death.

Vertaling (verkorte versie) van en commentaar op de wijsgerige verhandeling van de Nederlandse filosoof (1632-1677) over de betekenis van het christendom.

Combinatie van vertaling en uitleg van de 'Ethica', het hoofdwerk van de Nederlandse filosoof (1632-1677).

The introduction of chatGPT illustrates the rapid developments within Conversational Artificial Intelligence (CAI) technologies (Gordijn and Have 2023). Ethical reflection and analysis of CAI are c...

This volume consists of 21 papers delivered at an international Spinoza conference on Disguised and Overt Spinozism around 1700, held at the Erasmus University ...

The development of gene expression profiling and next-generation sequencing technologies have steered oncogenomics to the forefront of precision medicine. This created a need for harmonious cooperation between clinicians and researchers to increase access to precision oncology, despite multiple implementation challenges being encountered. The aim is to apply personalised treatment strategies early in cancer management, targeting tumour subtypes and actionable gene variants within the individual’s broader clinical risk profile and wellbeing. A knowledge-generating database linked to the South African Medical Research Council’s (...) Genomic Centre has been created for the application of personalised medicine, using an integrated service and research approach. Insights gained from patient experiences related to tumour heterogeneity, access to targeted therapies and incidental findings of pathogenic germline variants in tumour DNA, provided practice-changing evidence for the implementation of a cost-minimisation pathology-supported genetic testing strategy. Integrating clinical care with genomic research through data sharing advances personalised medicine and maximises precision oncology benefits. (shrink)

With technological possibilities in healthcare steadily increasing, more tools for digital cognitive rehabilitation become available. Acceptance of such technological advances is crucial for successful implementation. Therefore, we examined technology acceptance specifically for this form of rehabilitation in a sample of healthcare providers involved in cognitive rehabilitation. An adjusted version of the Technology Acceptance Model questionnaire was used, including the subscales for perceived usefulness, perceived ease of use, subjective norm, and intention to use, which all contribute to actual use of a (...) specific technology. Results indicate a generally favorable attitude toward the use of digital cognitive rehabilitation and positive responses toward the TAM constructs. Only for subjective norm, a neutral mean response was found, indicating that this could pose a potential obstacle toward implementation. Potential differences between subgroups of different age, gender, and professional background were assessed. Age and gender did not affect the attitude toward digital cognitive rehabilitation. Occupational therapists showed lower scores than healthcare psychologists and physiatrists with regard to perceived usefulness, possibly linked to a difference in operational and managerial tasks. The findings of his study stimulate further implementation of digital cognitive rehabilitation, where the role of subjective norms should be specifically considered. (shrink)

Parametric cognitive models are increasingly popular tools for analyzing data obtained from psychological experiments. One of the main goals of such models is to formalize psychological theories using parameters that represent distinct psychological processes. We argue that systematic quantitative reviews of parameter estimates can make an important contribution to robust and cumulative cognitive modeling. Parameter reviews can benefit model development and model assessment by providing valuable information about the expected parameter space, and can facilitate the more efficient design of experiments. (...) Importantly, parameter reviews provide crucial—if not indispensable—information for the specification of informative prior distributions in Bayesian cognitive modeling. From the Bayesian perspective, prior distributions are an integral part of a model, reflecting cumulative theoretical knowledge about plausible values of the model's parameters (Lee,2018). In this paper we illustrate how systematic parameter reviews can be implemented to generate informed prior distributions for the Diffusion Decision Model (DDM; Ratcliff and McKoon,2008), the most widely used model of speeded decision making. We surveyed the published literature on empirical applications of the DDM, extracted the reported parameter estimates, and synthesized this information in the form of prior distributions. Our parameter review establishes a comprehensive reference resource for plausible DDM parameter values in various experimental paradigms that can guide future applications of the model. Based on the challenges we faced during the parameter review, we formulate a set of general and DDM-specific suggestions aiming to increase reproducibility and the information gained from the review process. (shrink)

SummaryIntense, sustained nursing lengthens inter-birth intervals and is causally linked with low natural fertility. However, in traditional settings, the effects of such nursing on fertility are difficult to disentangle from those of nutrition. Results from an prospective, direct observational study of reproductive function in well-nourished Amele women who nurse intensively and persistently but who also have high fertility are here presented. Endocrine measures show that ovarian activity resumes by median 11·0 months postpartum. Median duration of postpartum amenorrhoea is 11·3 months, (...) time to next conception is 19·0 months, and the inter-birth interval is 28·0 months. Average life time fertility is 6·8. High fertility in Amele women is due both to refractoriness of reproductive function to suckling stimuli, and to maintenance of equivalent age-specific fertility rates across the reproductive life span. (shrink)

Overzicht van de invloed van klassieke auteurs op het werk van de Nederlandse wijsgeer.

Outside France the epistemology of G. Bachelard is unknown ; in France his influence is considerable, especially on philosophers like L. Althusser, M. Foucault, G. Canguilhem, J. Hyppolite, M. Serres, G. G. Granger, D. Lecourt and many others. Bachelard occupies a strategic point on the crossroads of all theoretical debates concerning science. The fact that he seems to give satisfactory answers on the problems which have risen after the breakdown of the logical-positivistic philosophy of science, justifies an exposition and evaluation (...) of his original contribution to philosophy. The author distinguishes the following items. 1. The determination of Bachelards philosophy as a scientific philosophy which is wedded to a history of the sciences, especially the natural sciences. 2. The 'systematicity' as the criterium of science against other, traditional, criteria like empiricalness, logical deducibility, correspondence with reality and so on. 3. The rectification-principle : the formation of a scientific system cannot be conceived otherwise than as the restructuring or reorganisation of the ruling system or system-sets. 4. The transformation of scientific knowledge shows many discontinuities in all its phases and branches. Bachelard calls them ruptures. 5. The translation of a theory into another, more coherent and comprehensive one, is baptised as a 'dialectisation' of the concept. By a dialectisation a system is both generalised and specified. Formal logic, which is based on identity and the principle of the excluded middle, is not able to interprete this dynamic aspect of scientific thinking. 6. Central in Bachelards philosophy is also the concept of recurrence. Each new organisation of the scientific system (global or partial) sheds new light on their history and their logical foundations. History has to be rewritten after each progress. Recurrence, however, also has systematic implications. Science always desimplifies its own evidences. 7. The scientist has to demolish the obstacles which he made himself by surcharging the content of the concepts not in use and by not assimilating them in the system. 8. Bachelards philosophy of science is both idealistic and realistic ; the phenomenology becomes phenomenotechnique under the hands and in the brains of the scientist. 9. He always denies (negativity) the earlier theories and objects by incorporating them in new relationships. 10. This constructive aspect of theory formation is the same in natural science and mathematics. Bachelard opposes the logical-positivistic idea that these are methodically dissimilar. In a critical commentary the author discusses the question of 'dialectical logic' in the sciences, in relation to some recent research in this field by I. Lakatos en Errol E. Harris. In his opinion the epistemology of Bachelard affords a creative renewal of the understanding of science, although further research is needed in many aspects. (shrink)

The traditional philosophical treatises on culture, who mostly started from neohumanistic inheritance, recently got a serious, though revolutionary partner for discussion in the person of Herbert Marcuse. The ideas, which this thinker launches on culture and society, are not loose propositions or emotionally determined interpretations, but form a structural theory, that earns further consideration. This article tries to give a survey of his opinions on this theme as well as a critical look at their suppositions and coherence. Eventually are discussed (...) Marcuse's concept of the prevailing culture as an affirmative culture, i.e. an attitude in which one accepts the existing social conditions and resigns to them. After that it discusses Marcuse's deepened interpretation of culture as a civilisation, in which the repression of the truely human needs and impulses is so to say institutionalised, and finally his matured judgement on the recovery of culture by means of the play-impulse and sufficient space for speculative and practical negation in a non-operational dimension. Retrospecting we stated that Marcuse is taking back now something of his original, marxistic aversion of the theoretical attitude, that is inaugured by the Greeks. One must also criticise his unilateral reviewing of the technical and social acquisitions of mankind. But his realising and objectifying of the old spiritual ideal of culture is no doubt a profit in relation to the neo-humanistic philosophy of culture. (shrink)

An accurate analysis of the text shows that the small treatises have a logical structure and a style which is in all aspects unspinozistic. The main points of difference are : a formalistic interpretation of mathematics‚ the opposition between mathematics and physics‚ slavish cartesianism‚ the presence of numerous pleonasms‚ carelessness of expression‚ parade of learning‚ prolixity‚ attention for irrelevant qualities of authors quoted‚ educational purpose. Together with De Vet’s demonstration that the author of SRR and RK is still alive in (...) 1693 (see Tijdschr. v. Filosofie 45‚ 1983) these arguments force us‚ to consign Spinoza’s authorship‚ recently still defended by Petry a.o.‚ to the realm of fancy. (shrink)

The Charmides is among Plato's most intriguing and perplexing dialogues. The range of subjects touched or treated is extremely wide: matters logical, epistemological, moral, ethical, political, and religious. In many cases, these are discussed in a highly inconclusive and aporetic way, especially when it comes to the subject of knowledge. Finally, the dialogue is also difficult on almost every level of its expression; mock-reasonings, misunderstandings, ironies, paradoxes, and perplexities abound. As a result, the run of its many arguments, both on (...) the short and the long range, and its overall structure are not easy to discern. If a text of such a character is to be made completely accessible, a full-scale commentary is required; it is much to be regretted, therefore, that there is no commentary in which the difficulties of the Greek, the argument, and the place of the philosophical problems in the development of Plato's thought are comprehensively and coherently explained. This monograph does not aspire to that status, but makes an essential contribution towards achieving that aim (in addition to the many other works in the field, Lamb's scrupulous translation of 1927 and Bloch's penetrating study of 1973 in particular) by presenting a detailed examination of forty-two passages of which the interpretation is disputed; many more minor problems are dealt with along the way. In all matters of interpretation, special attention has been paid to defining the exact place of the passage within the run of the, often intricate, argument. The result of this attention can also be observed in an analytical 'Summary of the contents of the Charmides'. (shrink)

Precision medicine research involving human biological material is becoming an increasingly central component of healthcare, and its potential is quickly growing due to rapid technological progress...

Precision Medicine is driven by the idea that the rapidly increasing range of relatively cheap and efficient self-tracking devices make it feasible to collect multiple kinds of phenotypic data. Advocates of N = 1 research emphasize the countless opportunities personal data provide for optimizing individual health. At the same time, using biomarker data for lifestyle interventions has shown to entail complex challenges. In this paper, we argue that researchers in the field of precision medicine need to address the performative dimension (...) of collecting data. We propose the fun-house mirror as a metaphor for the use of personal health data; each health data source yields a particular type of image that can be regarded as a ‘data mirror’ that is by definition specific and skewed. This requires competence on the part of individuals to adequately interpret the images thus provided. (shrink)